Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

AIMS: To determine the population pharmacokinetics of chlorproguanil, dapsone and the active metabolite of chlorproguanil, chlorcycloguanil; and to estimate the duration of parasitocidal activity for chlorpoguanil/dapsone against Plasmodium falciparum isolates of varying sensitivity. METHODS: Rich a...

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Detalhes bibliográficos
Main Authors: Simpson, Julie A, Hughes, Dyfrig, Manyando, Christine, Bojang, Kalifa, Aarons, Leon, Winstanley, Peter, Edwards, Geoffrey, Watkins, William A, Ward, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Pharmacokinetics & Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885012/
https://ncbi.nlm.nih.gov/pubmed/16487222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02567.x
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