Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance

AIMS: Organic nitrates, via nitric oxide (NO) release, induce vasodilatation and inhibit platelet aggregation. Development of nitrate tolerance in some vascular preparations may be associated with diminished responsiveness to NO. To date it is not known to what extent vascular tolerance to organic n...

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Bibliographic Details
Main Authors: Holmes, Andrew S, Chirkov, Yuliy Y, Willoughby, Scott R, Poropat, Susan, Pereira, Jeremy, Horowitz, John D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Pharmacodynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884829/
https://ncbi.nlm.nih.gov/pubmed/16187967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02437.x
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