Pharmacokinetic interaction between verapamil and everolimus in healthy subjects

AIMS: We sought to define the influence of verapamil, an inhibitor of CYP3A and P-glycoprotein, on the pharmacokinetics of everolimus, a substrate of this enzyme and transporter. METHODS: This was a two-period, single-sequence, crossover study in 16 healthy subjects. In period 1 subjects received a...

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Autores principales: Kovarik, J M, Beyer, D, Bizot, M N, Jiang, Q, Allison, M J, Schmouder, R L
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2005
Materias:
Drug Interaction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884822/
https://ncbi.nlm.nih.gov/pubmed/16187976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02434.x
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