The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria

AIMS: We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria. METHODS: AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method. RESULTS: AQ was not detectable beyond day 3 postdose...

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Dettagli Bibliografici
Autori principali: Hombhanje, FW, Hwaihwanje, I, Tsukahara, T, Saruwatari, J, Nakagawa, M, Osawa, H, Paniu, MM, Takahashi, N, Lum, JK, Aumora, B, Masta, A, Sapuri, M, Kobayakawa, T, Kaneko, A, Ishizaki, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2005
Soggetti:
Pharmacokinetics/Dosing/Disposition
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884785/
https://ncbi.nlm.nih.gov/pubmed/15752375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02257.x
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