Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling

BACKGROUND: Controversy remains about the interaction between mycophenolate mofetil (MMF) and the calcineurin inhibitors cyclosporin (CsA) and tacrolimus (TACR). The need to double the dose of MMF in case of CsA co-administration to achieve the same mycophenolic acid (MPA) levels as in TACR co-admin...

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Detalhes bibliográficos
Main Authors: Cremers, Serge, Schoemaker, Rik, Scholten, Eduard, den Hartigh, Jan, König-Quartel, Jacqueline, van Kan, Eric, Paul, Leendert, de Fijter, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884762/
https://ncbi.nlm.nih.gov/pubmed/16120063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02398.x
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