Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients

AIM: To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence. METHODS: A population pharmacokinetic model was developed using P-Pharm software for rac-, (R)- and (S)-methadone using data (8–13 plasma samples pe...

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Detalhes bibliográficos
Main Authors: Foster, David J R, Somogyi, Andrew A, White, Jason M, Bochner, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884530/
https://ncbi.nlm.nih.gov/pubmed/15151520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02079.x
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