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Protein binding and α:β anomer ratio of dihydroartemisinin in vivo
AIMS: To determine the ratio of α:β anomers and the protein binding of dihydroartemisinin (DHA) in vivo. METHODS: 10-[(3)H]-DHA was synthesized by reduction of artemisinin with sodium boro-[(3)H]-hydride and purified with preparative thin layer chromatography. A solution of (3)H-DHA (2000 ng in 20 µ...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884468/ https://ncbi.nlm.nih.gov/pubmed/15025754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02045.x |
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