The antiangiogenic agent TNP-470 requires p53 and p21(CIP/WAF) for endothelial cell growth arrest
Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2000
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18841/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11070090/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.23.12782 |
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