The antiangiogenic agent TNP-470 requires p53 and p21(CIP/WAF) for endothelial cell growth arrest

Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Yeh, Jing-Ruey J., Mohan, Royce, Crews, Craig M.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18841/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11070090/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.23.12782
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