Rifampin for therapy of experimental pneumococcal meningitis in rabbits.

Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Nau, R, Kaye, K, Sachdeva, M, Sande, E R, Täuber, M G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188176/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8067762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.5.1186
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