Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model

BACKGROUND: Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive motor and cognitive dysfunction. Caused by an expanded polyglutamine tract in ataxin 1 (ATXN1), SCA1 pathogenesis involves a multifactorial process that likely begins wi...

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Bibliographische Detailangaben
Hauptverfasser: Watase, Kei, Gatchel, Jennifer R, Sun, Yaling, Emamian, Effat, Atkinson, Richard, Richman, Ronald, Mizusawa, Hidehiro, Orr, Harry T, Shaw, Chad, Zoghbi, Huda Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1880853/
https://ncbi.nlm.nih.gov/pubmed/17535104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040182
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