Brain and Optic System Pathology in Hypocholesterolemic Dogs Treated with a Competitive Inhibitor of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase

The cholesterol lowering compound lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34 HMG CoA reductase), was given in nine separate experiments to normocholesterolemic dogs at rates up to 180 times the maximum therapeutic dose in man (1 mg/kg/day). Me...

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Main Authors: Berry, P. H., MacDonald, J. S., Alberts, A. W., Molon-Noblot, S., Chen, J. S., Lo, C.-Y. L., Greenspan, M. D., Allen, H., Durand-Cavagna, G., Jensen, R., Bailly, Y., Delort, P., Duprat, P.
Format: Artigo
Sprog:Inglês
Udgivet: 1988
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1880766/
https://ncbi.nlm.nih.gov/pubmed/3414776
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