In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.

The disposition and metabolic fate of 3'-deoxy-2',3'-didehydrothymidine (D4T) were evaluated both in isolated hepatocytes and in nonhuman primates. Rapid formation of thymine and beta-aminoisobutyric acid (BAIBA) occurred following incubation of hepatocytes with 10 microM [5(-3)H]D4T. Substantial le...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Cretton, E M, Zhou, Z, Kidd, L B, McClure, H M, Kaul, S, Hitchcock, M J, Sommadossi, J P
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188075/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1816
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