In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.

The disposition and metabolic fate of 3'-deoxy-2',3'-didehydrothymidine (D4T) were evaluated both in isolated hepatocytes and in nonhuman primates. Rapid formation of thymine and beta-aminoisobutyric acid (BAIBA) occurred following incubation of hepatocytes with 10 microM [5(-3)H]D4T. Substantial le...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Cretton, E M, Zhou, Z, Kidd, L B, McClure, H M, Kaul, S, Hitchcock, M J, Sommadossi, J P
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 1993
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188075/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1816
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!