Alterations in pharmacokinetics and protein binding behavior of cefazolin in endotoxemic rats.

The possible alterations in the pharmacokinetics and protein binding behavior of the beta-lactam antibiotic cefazolin (CEZ) were investigated in endotoxemic rats induced by Klebsiella pneumoniae O3 lipopolysaccharide (LPS). LPS (250 micrograms/kg of body weight) was infused for 20 to 30 min 2 h befo...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Nadai, M, Hasegawa, T, Kato, K, Wang, L, Nabeshima, T, Kato, N
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239584/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1781
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