Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1.

An increase in glomerular size occurs in normal maturation after subtotal renal ablation and disease states such as diabetes mellitus. The role that growth hormone (GH), growth hormone releasing factor (GHRF), and insulinlike growth factor-1 (IGF-1) play in these processes has been investigated usin...

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Detalhes bibliográficos
Main Authors: Doi, T., Striker, L. J., Quaife, C., Conti, F. G., Palmiter, R., Behringer, R., Brinster, R., Striker, G. E.
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1880691/
https://ncbi.nlm.nih.gov/pubmed/3132856
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