The time of administration of 3'-azido-3'-deoxythymidine (AZT) determines its host toxicity with possible relevance to AZT chemotherapy.

3'-Azido-3'-deoxythymidine (AZT) is the drug most widely used in the treatment of AIDS. Its major drug-related toxicity is bone marrow suppression, which limits the dose of AZT that can be used. It is essential that AZT be phosphorylated for antiviral effect. We have recently demonstrated that thymi...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Zhang, R, Lu, Z, Diasio, C R, Liu, T, Soong, S J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8239582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.9.1771
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