Effects of discontinuation of zidovudine treatment on zidovudine sensitivity of human immunodeficiency virus type 1 isolates.

Zidovudine treatment of individuals infected with human immunodeficiency virus type 1 (HIV-1) results in HIV-1 isolates with a reduced zidovudine sensitivity in vitro. This reduction is due to mutations causing amino acid substitutions at five codons (41, 67, 70, 215, and 219) on the reverse transcr...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Boucher, C A, van Leeuwen, R, Kellam, P, Schipper, P, Tijnagel, J, Lange, J M, Larder, B A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8103317/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.7.1525
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