pol mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivo.

Specific mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene that cause zidovudine (3'-azido-2',3'-dideoxythymidine; AZT) and didanosine (2',3'-dideoxyinosine; ddI) resistance were studied. The 50% inhibitory concentrations (IC50s) of nucleosides for cloned viruses containing these...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Eron, J J, Chow, Y K, Caliendo, A M, Videler, J, Devore, K M, Cooley, T P, Liebman, H A, Kaplan, J C, Hirsch, M S, D'Aquila, R T
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187998/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7689822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.7.1480
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