The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.

Lignende værker

• Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.
  af: Gu, Z, et al.
  Udgivet: (1994)
• Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.
  af: Cherry, E, et al.
  Udgivet: (1997)
• Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.
  af: Gao, Q, et al.
  Udgivet: (1993)
• Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.
  af: Gu, Z, et al.
  Udgivet: (1992)
• Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.
  af: Rajagopalan, P, et al.
  Udgivet: (1996)