Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

Artemisinin is an important new antimalarial agent containing a bridged endoperoxide. The in vitro antimalarial activity of an artemisinin derivative, arteether, is antagonized by two iron chelators, pyridoxal benzoylhydrazone and 1,2-dimethyl-3-hydroxypyrid-4-one. Similarly, the acute toxicity of a...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Meshnick, S R, Yang, Y Z, Lima, V, Kuypers, F, Kamchonwongpaisan, S, Yuthavong, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8517699/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.5.1108
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