Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).
Artemisinin is an important new antimalarial agent containing a bridged endoperoxide. The in vitro antimalarial activity of an artemisinin derivative, arteether, is antagonized by two iron chelators, pyridoxal benzoylhydrazone and 1,2-dimethyl-3-hydroxypyrid-4-one. Similarly, the acute toxicity of a...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1993
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187911/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8517699/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.5.1108 |
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