The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells

Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which is the primary product of 15-LOX-1 metabolism of linoleic acid, restores apoptosis. Nonsteroida...

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Bibliografiske detaljer
Main Authors: Shureiqi, Imad, Jiang, Wei, Zuo, Xiangsheng, Wu, Yuanqing, Stimmel, Julie B., Leesnitzer, Lisa M., Morris, Jeffrey S., Fan, Hui-Zhen, Fischer, Susan M., Lippman, Scott M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC187904/
https://ncbi.nlm.nih.gov/pubmed/12909723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1631086100
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