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The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation

Phosphatidylinositol-5-phosphate (PI-5-P) is a newly identified phosphoinositide with characteristics of a signaling lipid but no known cellular function. PI-5-P levels are controlled by the type II PI-5-P 4-kinases (PIP4K IIs), a family of kinases that converts PI-5-P into phosphatidylinositol-4,5-...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carricaburu, Valerie, Lamia, Katja A., Lo, Elizabeth, Favereaux, Laetitia, Payrastre, Bernard, Cantley, Lewis C., Rameh, Lucia E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187868/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897244/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1734038100
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