Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice

Heparin cofactor II (HCII) specifically inhibits thrombin action at sites of injured arterial wall, and patients with HCII deficiency exhibit advanced atherosclerosis. However, the in vivo effects and the molecular mechanism underlying the action of HCII during vascular remodeling remain elusive. To...

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Detalhes bibliográficos
Main Authors: Aihara, Ken-ichi, Azuma, Hiroyuki, Akaike, Masashi, Ikeda, Yasumasa, Sata, Masataka, Takamori, Nobuyuki, Yagi, Shusuke, Iwase, Takashi, Sumitomo, Yuka, Kawano, Hirotaka, Yamada, Takashi, Fukuda, Toru, Matsumoto, Takahiro, Sekine, Keisuke, Sato, Takashi, Nakamichi, Yuko, Yamamoto, Yoko, Yoshimura, Kimihiro, Watanabe, Tomoyuki, Nakamura, Takashi, Oomizu, Akimasa, Tsukada, Minoru, Hayashi, Hideki, Sudo, Toshiki, Kato, Shigeaki, Matsumoto, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1878511/
https://ncbi.nlm.nih.gov/pubmed/17549254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27095
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