Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice

Heparin cofactor II (HCII) specifically inhibits thrombin action at sites of injured arterial wall, and patients with HCII deficiency exhibit advanced atherosclerosis. However, the in vivo effects and the molecular mechanism underlying the action of HCII during vascular remodeling remain elusive. To...

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Main Authors: Aihara, Ken-ichi, Azuma, Hiroyuki, Akaike, Masashi, Ikeda, Yasumasa, Sata, Masataka, Takamori, Nobuyuki, Yagi, Shusuke, Iwase, Takashi, Sumitomo, Yuka, Kawano, Hirotaka, Yamada, Takashi, Fukuda, Toru, Matsumoto, Takahiro, Sekine, Keisuke, Sato, Takashi, Nakamichi, Yuko, Yamamoto, Yoko, Yoshimura, Kimihiro, Watanabe, Tomoyuki, Nakamura, Takashi, Oomizu, Akimasa, Tsukada, Minoru, Hayashi, Hideki, Sudo, Toshiki, Kato, Shigeaki, Matsumoto, Toshio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1878511/
https://ncbi.nlm.nih.gov/pubmed/17549254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27095
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