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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P-STAT3), which activates many genes, including the STAT3 gene itself. The resulting increase in the concentration of unphosphorylated STAT3 (U-S...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1877751/ https://ncbi.nlm.nih.gov/pubmed/17510282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1553707 |
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