Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

The principal pathological features of Alzheimer's disease (AD) are extracellular amyloid plaques and intracellular neurofibrillary tangles, the latter composed of the microtubule-binding protein tau assembled into paired helical and straight filaments. Recent studies suggest that these pathological...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Gamblin, T. Chris, Chen, Feng, Zambrano, Angara, Abraha, Aida, Lagalwar, Sarita, Guillozet, Angela L., Lu, Meiling, Fu, Yifan, Garcia-Sierra, Francisco, LaPointe, Nichole, Miller, Richard, Berry, Robert W., Binder, Lester I., Cryns, Vincent L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1630428100
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