The role of Rel(Mtb)-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice

Long-term survival of nonreplicating Mycobacterium tuberculosis (Mtb) is ensured by the coordinated shutdown of active metabolism through a broad transcriptional program called the stringent response. In Mtb, this response is initiated by the enzymatic action of Rel(Mtb) and deletion of rel(Mtb) pro...

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Autors principals: Dahl, John L., Kraus, Carl N., Boshoff, Helena I. M., Doan, Bernard, Foley, Korrie, Avarbock, David, Kaplan, Gilla, Mizrahi, Valerie, Rubin, Harvey, Barry, Clifton E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC187750/
https://ncbi.nlm.nih.gov/pubmed/12897239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1631248100
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