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The RING Finger Domain of MDM2 Is Essential for MDM2-mediated TGF-β Resistance
In this study, we attempt to gain insights into the molecular mechanism underlying MDM2-mediated TGF-β resistance. MDM2 renders cells refractory to TGF-β by overcoming a TGF-β–induced G1 cell cycle arrest. Because the TGF-β resistant phenotype is reversible upon removal of MDM2, MDM2 likely confers...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1877115/ https://ncbi.nlm.nih.gov/pubmed/17429071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-09-0844 |
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