Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.

We have studied the antiproliferative effects of mevinolin (lovastatin), an inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, on the protozoan parasite Trypanosoma (Schizotrypanum) cruzi and its ability to potentiate the action of specific ergosterol biosynthesis inhibitors, such as ket...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Urbina, J A, Lazardi, K, Marchan, E, Visbal, G, Aguirre, T, Piras, M M, Piras, R, Maldonado, R A, Payares, G, de Souza, W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187710/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460926/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.3.580
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