BRCA2 Is Inactivated Late in the Development of Pancreatic Intraepithelial Neoplasia : Evidence and Implications

Patients harboring germline BRCA2 mutations are at an increased risk of developing pancreatic cancer. We investigated the prevalence of biallelic inactivation of BRCA2 in the presumed precursors to invasive pancreatic ductal carcinomas, pancreatic intraepithelial neoplasia (PanIN). Surgical resectio...

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Bibliographic Details
Main Authors: Goggins, Michael, Hruban, Ralph H., Kern, Scott E.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2000
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876938/
https://ncbi.nlm.nih.gov/pubmed/10793087
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