The Indispensability of Heme Oxygenase-1 in Protecting against Acute Heme Protein-Induced Toxicity in Vivo

Heme oxygenase (HO) is the rate limiting enzyme in the degradation of heme, and its isozyme, HO-1, may protect against tissue injury. One posited mechanism is the degradation of heme released from destabilized heme proteins. We demonstrate that HO-1 is a critical protectant against acute heme protei...

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Main Authors: Nath, Karl A., Haggard, Jill J., Croatt, Anthony J., Grande, Joseph P., Poss, Kenneth D., Alam, Jawed
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2000
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876926/
https://ncbi.nlm.nih.gov/pubmed/10793064
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