Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by Telomerase

Exogenous expression of hTERT, the catalytic component of telomerase, is sufficient for the immortalization of human fibroblasts but insufficient for the immortalization of human foreskin keratinocytes (HFKs) and human mammary epithelial cells (HMECs). These latter cell types can overcome senescence...

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Main Authors: Farwell, D. Gregory, Shera, Katherine A., Koop, Jennifer I., Bonnet, George A., Matthews, Connie P., Reuther, Gary W., Coltrera, Marc D., McDougall, James K., Klingelhutz, Aloysius J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2000
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876907/
https://ncbi.nlm.nih.gov/pubmed/10793065
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