Structure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro.

An in vitro investigation of the structure-activity profiles for a range of 9-anilinoacridines on drug-resistant Plasmodium falciparum is reported. C-3, 6-diamino substitution, low lipophilicity, and high pKa values substantially increased the activities of the 9-anilinoacridines tested. There appea...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Chavalitshewinkoon, P, Wilairat, P, Gamage, S, Denny, W, Figgitt, D, Ralph, R
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1993
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8384810/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.3.403
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