Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF

We previously demonstrated that in vitro stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes, class switch recombination (CSR), induction of the E2A-encoded transcription factor E47, and activation-induced cytidine deaminase (AID) which is nec...

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Bibliografiske detaljer
Main Authors: Frasca, Daniela, Riley, Richard L., Blomberg, Bonnie B.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876723/
https://ncbi.nlm.nih.gov/pubmed/17067770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2006.09.003
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