Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

Dysfunction of mitochondrial complex I is associated with a wide spectrum of neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of complex I leads to degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc), as seen in PD, through ac...

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Detalhes bibliográficos
Main Authors: Perier, Celine, Bové, Jordi, Wu, Du-Chu, Dehay, Benjamin, Choi, Dong-Kug, Jackson-Lewis, Vernice, Rathke-Hartlieb, Silvia, Bouillet, Philippe, Strasser, Andreas, Schulz, Jörg B., Przedborski, Serge, Vila, Miquel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876588/
https://ncbi.nlm.nih.gov/pubmed/17483459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609874104
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