Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs

TRIF is an adaptor protein associated with the signaling by Toll-like receptor (TLR)3 and TLR4 for the induction of type I IFNs. Here, we demonstrate a mechanism by which TLR signaling controls cell proliferation and survival. We show that TLR3 and TLR4 can induce cell cycle entry via TRIF, which ta...

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Détails bibliographiques
Auteurs principaux: Hasan, Uzma A., Caux, Christophe, Perrot, Ivan, Doffin, Anne-Claire, Menetrier-Caux, Christine, Trinchieri, Giorgio, Tommasino, Massimo, Vlach, Jaromir
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876569/
https://ncbi.nlm.nih.gov/pubmed/17463087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700664104
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