Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats

BACKGROUND: The most common pathologic form of pulmonary fibrosis arises from excessive deposition of extracellular matrix proteins such as collagen. The 47 kDa heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role during the processing and...

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Bibliographic Details
Main Authors: Hagiwara, Satoshi, Iwasaka, Hideo, Matsumoto, Shigekiyo, Noguchi, Takayuki
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876458/
https://ncbi.nlm.nih.gov/pubmed/17504519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-37
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