Overproduction of 3'-aminoglycoside phosphotransferase type I confers resistance to tobramycin in Escherichia coli.

Escherichia coli HM69, isolated from urine, was resistant to high levels of kanamycin (MIC, > 1,000 micrograms/ml) and a low level of tobramycin (MIC, 8 micrograms/ml). Phosphocellulose paper-binding assays and molecular cloning indicated that resistance to both aminoglycosides was due to synthesis...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Menard, R, Molinas, C, Arthur, M, Duval, J, Courvalin, P, Leclercq, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381641/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.1.78
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