High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.

Plasmid pMP1-1 in Escherichia coli L-0 encodes aminoglycoside (AG) 3'-phosphotransferase II [APH(3')-II]. This enzyme modifies and confers high-level resistance to kanamycin. Although amikacin is a substrate for APH(3')-II, strain L-0(pMP1-1) is susceptible to amikacin. Plasmid pMP1-2...

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Bibliografski detalji
Glavni autori: Perlin, M H, Lerner, S A
Format: Artigo
Jezik:Inglês
Izdano: 1986
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC176380/
https://ncbi.nlm.nih.gov/pubmed/2424366
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