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High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.

Plasmid pMP1-1 in Escherichia coli L-0 encodes aminoglycoside (AG) 3'-phosphotransferase II [APH(3')-II]. This enzyme modifies and confers high-level resistance to kanamycin. Although amikacin is a substrate for APH(3')-II, strain L-0(pMP1-1) is susceptible to amikacin. Plasmid pMP1-2 is a spontaneo...

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Published in:Antimicrob Agents Chemother
Main Authors: Perlin, M H, Lerner, S A
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176380/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2424366/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.2.216
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