Assembly of the SMRT–histone deacetylase 3 repression complex requires the TCP-1 ring complex

The acetylation of histone tails is a primary determinant of gene activity. Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for HDAC enzyme activity. Here we report that HDAC3 interacts with SMRT only after priming by cellular chaperones including the TCP-1 ring complex...

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Pubblicato in:	Genes Dev
Autori principali:	Guenther, Matthew G., Yu, Jiujiu, Kao, Gary D., Yen, Tim J., Lazar, Mitchell A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2002
Soggetti:	Research Communication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502735/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1037502
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