Lipoatrophic diabetes in Irs1(−/−)/Irs3(−/−) double knockout mice

Based on the phenotypes of knockout mice and cell lines, as well as pathway-specific analysis, the insulin receptor substrates IRS-1, IRS-2, IRS-3, and IRS-4 have been shown to play unique roles in insulin signal transduction. To investigate possible functional complementarity within the IRS family,...

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Autori principali: Laustsen, Palle G., Michael, M. Dodson, Crute, Barbara E., Cohen, Shmuel E., Ueki, Kohjiro, Kulkarni, Rohit N., Keller, Susanna R., Lienhard, Gustav E., Kahn, C. Ronald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2002
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC187498/
https://ncbi.nlm.nih.gov/pubmed/12502742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1034802
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