Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma

Existing microarray-based approaches for screening of DNA methylation are hampered by a number of shortcomings, such as the introduction of bias by DNA copy-number imbalances in the test genome and negligence of tissue-specific methylation patterns. We developed a method designated array-based profi...

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Autori principali: Pfister, Stefan, Schlaeger, Christof, Mendrzyk, Frank, Wittmann, Andrea, Benner, Axel, Kulozik, Andreas, Scheurlen, Wolfram, Radlwimmer, Bernhard, Lichter, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2007
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874664/
https://ncbi.nlm.nih.gov/pubmed/17344319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm094
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