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Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that forms in the presence of divalent cations such as Mg(2+). Differential scanning calorimetry, UV thermal denaturation, isothermal titration calorimetry and competition dialy...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1874653/ https://ncbi.nlm.nih.gov/pubmed/17369273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm037 |
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