In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27

The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies of drugs which interact with the minor groove of DNA, some of which are used...

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Bibliographic Details
Main Authors: Acosta-Reyes, Francisco J., Dardonville, Christophe, de Koning, Harry P., Natto, Manal, Subirana, Juan A., Campos, J. Lourdes
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2014
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051503/
https://ncbi.nlm.nih.gov/pubmed/24914972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S139900471400697X
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