Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that forms in the presence of divalent cations such as Mg(2+). Differential scanning calorimetry, UV thermal denaturation, isothermal titration calorimetry and competition dialy...

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Hlavní autoři: Barceló, Francisca, Scotta, Claudia, Ortiz-Lombardía, Miguel, Méndez, Carmen, Salas, José A., Portugal, José
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874653/
https://ncbi.nlm.nih.gov/pubmed/17369273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm037
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