Chemical modification of Ce(IV)/EDTA-based artificial restriction DNA cutter for versatile manipulation of double-stranded DNA

A monophosphate group was attached to the terminus of pseudo-complementary peptide nucleic acid (pcPNA), and two of thus modified pcPNAs were combined with Ce(IV)/EDTA for site-selective hydrolysis of double-stranded DNA. The site-selective DNA scission was notably accelerated by this chemical modif...

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Bibliographic Details
Main Authors: Yamamoto, Yoji, Mori, Masao, Aiba, Yuichiro, Tomita, Takafumi, Chen, Wen, Zhou, Jing-Min, Uehara, Akihiko, Ren, Yi, Kitamura, Yoshihito, Komiyama, Makoto
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874645/
https://ncbi.nlm.nih.gov/pubmed/17376805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm052
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