The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity

AIMS: To examine the effects of an oral contraceptive containing ethinyloestradiol and norgestrel on intestinal and hepatic CYP3A activity using midazolam as a probe substrate. METHODS: In a nonblinded sequential study, nine healthy women received simultaneous doses of intravenous midazolam (0.05 mg...

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Autori principali: Belle, Donna J, Callaghan, John T, Gorski, J Christopher, Maya, Juan F, Mousa, Omiema, Wrighton, Steven A, Hall, Stephen D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2002
Soggetti:
Drug Disposition
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874548/
https://ncbi.nlm.nih.gov/pubmed/11849197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01521.x
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