Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet®) with concomitant administration of ketoconazole in healthy subjects

AIMS: To evaluate whether the potent CYP3A4 inhibitor ketoconazole has any influence on the pharmacokinetic and electrocardiographic parameters of the antimalarial co-artemether (artemether-lumefantrine) in healthy subjects. METHODS: Sixteen subjects were randomized in an open-label, two period cros...

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Détails bibliographiques
Auteurs principaux: Lefèvre, Gilbert, Carpenter, Polly, Souppart, Claire, Schmidli, Heinz, McClean, Mark, Stypinski, Daria
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2002
Sujets:
Pharmacokinetics/Pharmacodynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874456/
https://ncbi.nlm.nih.gov/pubmed/12445027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01696.x
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